Key result
Anthracyclines induced dose-dependent cardiotoxicity in zebrafish embryos, with doxorubicin causing the greatest toxicity (LC50 31.2 μM) and daunorubicin the least (LC50 122.7 μM).
Why the study?
Do anthracyclines induce dose-dependent cardiotoxicity and developmental defects in early developing zebrafish embryos?
Do anthracyclines induce dose-dependent cardiotoxicity and developmental defects in early developing zebrafish embryos?
Anthracyclines induce dose-dependent cardiotoxicity and developmental defects in zebrafish embryos, suggesting zebrafish as a valuable model for assessing drug-induced developmental cardiotoxicity.
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Zebrafish may model anthracycline developmental cardiotoxicity; leaves open human translation.
Han et al. (2014) studied Drug-induced cardiotoxicity. Anthracyclines was evaluated on LC50 values at 72 h post-fertilization. Anthracyclines induced dose-dependent cardiotoxicity in zebrafish embryos, with doxorubicin causing the greatest toxicity (LC50 31.2 μM) and daunorubicin the least (LC50 122.7 μM).
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