Why the study?
Does persistent overexpression of Pgam2 modify cardiac energy metabolism and function in mice?
Does persistent overexpression of Pgam2 modify cardiac energy metabolism and function in mice?
Constitutive overexpression of the glycolytic enzyme Pgam2 in mouse hearts alters energy metabolism and reduces cardiac stress resistance, highlighting the role of glucose metabolism in heart failure pathogenesis.
Pgam2 overexpression data in mice leave open its role in human heart failure pathogenesis; warrant targeted validation studies.
No takes yet. Share an insight, caveat, or question.
Okuda et al. (2013) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: