November 11, 2016AJP Heart and Circulatory Physiology

Dynamical mechanisms of phase-2 early afterdepolarizations in human ventricular myocytes: insights from bifurcation analyses of two mathematical models

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Population

Two mathematical models of human ventricular myocytes

Design

Preclinical

Authors

YKYasutaka KurataKanazawa Medical University KTKunichika TsumotoKanazawa Medical University KHKenshi HayashiKanazawa University

Discussion

Member takes

Implication

Hypothesis-generating for EAD suppression via INCX; leaves open clinical translation from animal models.

Structured PICO

Population

Two mathematical models of human ventricular myocytes

Intervention

Bifurcation analyses and numerical simulations modifying ion currents (IKr, IKs, ICaL, INCX, INaK) and intracellular Ca2+/Na+ handling

Outcome

Initiation, termination, and modulation of phase-2 early afterdepolarizations (EADs)surrogate

Computational modeling demonstrates that phase-2 early afterdepolarization formation is strongly affected by intracellular ion concentrations and does not necessarily require IKs.

Cite This Study

Kurata et al. (2016) studied this question.

synapsesocial.com/papers/6a205aeee9ca693ff1e734dc https://doi.org/10.1152/ajpheart.00115.2016

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Dynamical mechanisms of phase-2 early afterdepolarizations in human ventricular myocytes: insights from bifurcation analyses of two mathematical models

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Dynamical mechanisms of phase-2 early afterdepolarizations in human ventricular myocytes: insights from bifurcation analyses of two mathematical models

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider