July 1, 1988European Heart JournalOpen Access

Long-term efficacy of oral encainide in frequent and repetitive ventricular arrhythmias

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Why the study?

Does oral encainide reduce the frequency of ventricular arrhythmias in patients with chronic high-frequency ventricular arrhythmias or NSVT?

Population

28 patients

Design

Cohort

Follow-up

36 months

Authors

MBMaria Grazia BongiorniElectrophysiology DLD LevoratoOspedale Santa Chiara CAC. ArlottaOspedale Maggiore

Discussion

Member takes

Implication

May aid arrhythmia suppression in observational cohorts; leaves open randomized confirmation of net clinical benefit.

Structured PICO

Does oral encainide reduce the frequency of ventricular arrhythmias in patients with chronic high-frequency ventricular arrhythmias or NSVT?

Population

28 patients (14 with chronic high-frequency ventricular arrhythmias and 14 with chronic frequent episodes of non-sustained ventricular tachycardia [NSVT])

Intervention

Oral encainide (dose-titration period followed by long-term maintenance)

Outcome

Reduction in average hourly frequency of isolated premature ventricular complexes (PVC) and non-sustained ventricular tachycardia (NSVT) episodessurrogate

Oral encainide effectively reduces the frequency of PVCs and NSVT without impairing left ventricular function, though severe proarrhythmic effects (sustained VT) may occur in patients with marked LV impairment.

Cite This Study

Bongiorni et al. (1988) studied this question.

synapsesocial.com/papers/6a205cd7e6386eb04298f7ae https://doi.org/10.1093/eurheartj/9.7.765

Topics

Echocardiography

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Long-term efficacy of oral encainide in frequent and repetitive ventricular arrhythmias

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Long-term efficacy of oral encainide in frequent and repetitive ventricular arrhythmias

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider