Key result
Radiofrequency catheter ablation was superior to antiarrhythmic drugs for maintaining freedom from recurrent atrial fibrillation or atrial tachycardia at 4 years (72.7% vs 56.5%, P=0.017).
Why the study?
Does radiofrequency catheter ablation reduce recurrent atrial fibrillation/atrial tachycardia compared to antiarrhythmic drugs in patients with paroxysmal atrial fibrillation?
RCT (n=198)
randomly assigned
Does radiofrequency catheter ablation reduce recurrent atrial fibrillation/atrial tachycardia compared to antiarrhythmic drugs in patients with paroxysmal atrial fibrillation?
Absolute Event Rate: 72.7% vs 56.5%
p-value: p=0.017
With follow-up extended to 4 years, radiofrequency catheter ablation remains superior to antiarrhythmic drugs for maintaining sinus rhythm and improving quality of life in patients with paroxysmal atrial fibrillation.
No takes yet. Share an insight, caveat, or question.
Supports first-line ablation in paroxysmal AF; extends randomized superiority to 4 years.
Pappone et al. (2011) conducted an RCT in paroxysmal atrial fibrillation (n=198). Radiofrequency catheter ablation (RFA) vs. Antiarrhythmic drugs (AADs) was evaluated on free of recurrent atrial fibrillation/atrial tachycardia (p=0.017). Radiofrequency catheter ablation was superior to antiarrhythmic drugs for maintaining freedom from recurrent atrial fibrillation or atrial tachycardia at 4 years (72.7% vs 56.5%, P=0.017).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: