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September 10, 2018Psychological MedicineOpen Access

Heart rate variability during a cognitive reappraisal task in female patients with borderline personality disorder: the role of comorbid posttraumatic stress disorder and dissociation

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Key result

Female borderline personality disorder patients with comorbid PTSD exhibited significantly lower high-frequency heart rate variability during an emotion regulation task compared to those without PTSD and healthy controls.

Why the study?

Does comorbid PTSD affect high-frequency heart rate variability during an emotion regulation task in female patients with borderline personality disorder?

Population

84 female participants, including 57 patients with borderline personality disorder and 27 healthy controls.

Comparison

Emotion regulation task. vs Healthy controls and BPD patients without PTSD.

Design

Cross-sectional

Authors

AKAnnegret Krause-UtzJWJulia-Caroline WaltherSLStefanie Lis

Discussion

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Overview

May warrant PTSD screening in BPD autonomic assessments; leaves open causality and clinical utility pending longitudinal data.

Study Design

Type

Observational (n=84)

Multicenter

No

Structured PICO

Does comorbid PTSD affect high-frequency heart rate variability during an emotion regulation task in female patients with borderline personality disorder?

P
Population
84 women aged 18-55, including 57 with borderline personality disorder (20 with comorbid PTSD) and 27 healthy controls, who underwent an emotion regulation task.
E
Exposure
Emotion regulation task (attending or down-regulating emotions to neutral, positive, and negative images using cognitive reappraisal).
C
Comparator
Healthy controls and BPD patients without PTSD.
O
Outcome
High-frequency heart rate variability (HF-HRV) during resting-state and emotion regulation task.surrogate

Main Result

p-value: p=0.002

Reduced high-frequency heart rate variability in borderline personality disorder is specifically associated with comorbid PTSD rather than BPD alone.

Limitations

  • Only women were included, limiting generalizability to male populations
  • Lack of a control group of PTSD patients without BPD
  • Potential confounding effects of comorbidities other than PTSD
  • Ecological validity of the emotion regulation paradigm may be limited

Cite This Study

Krause-Utz et al. (2018) conducted an observational in Borderline personality disorder with or without comorbid PTSD (n=84). Comorbid PTSD in Borderline Personality Disorder vs. BPD without PTSD and Healthy Controls was evaluated on High-frequency heart rate variability (HF-HRV) during an emotion regulation task (p=0.002). Female borderline personality disorder patients with comorbid PTSD exhibited significantly lower high-frequency heart rate variability during an emotion regulation task compared to those without PTSD and healthy controls.

synapsesocial.com/papers/6a205da967e003a2985adef9https://doi.org/10.1017/s0033291718002489
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Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Resting heart rate variability predicts self-reported difficulties in emotion regulation: a focus on different facets of emotion regulation2015 · 395 citations
  2. 2Dissociation and Alterations in Brain Function and Structure: Implications for Borderline Personality Disorder2017 · 113 citations