Why the study?
Does ductus arteriosus ligation induce pulmonary hypertension and vascular remodeling in fetal sheep?
Does ductus arteriosus ligation induce pulmonary hypertension and vascular remodeling in fetal sheep?
Ductus arteriosus ligation in fetal sheep induces pulmonary hypertension and vascular remodeling, characterized by increased ventricular weight ratio and medial thickness in small vessels.
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Provides fetal sheep model of post-ligation ventricular remodeling; leaves open translation to human PDA or neonatal PH.
Belik et al. (1994) studied this question.
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