Key result
A 72-year-old woman with COVID-19 pneumonia and acute ischemic stroke developed apical takotsubo cardiomyopathy, likely due to sympathetic stimulation and catecholamine surge.
Case Report (n=1)
No
This report highlights the first known case of the apical variant of takotsubo cardiomyopathy in a COVID-19 patient presenting with stroke.
Apical takotsubo may complicate COVID-19 stroke; extends case reports of cardiac involvement but remains hypothesis-generating.
COVID-19 is a pandemic that started in Wuhan city, Hubei province in China in December 2019 and is associated with high morbidity and mortality. It is characterized by a heightened inflammatory and prothrombotic state that are known to cause various cardiovascular manifestations such as thromboembolism, acute coronary syndrome and stroke. We here present a 72-year-old woman with multiple cardiovascular risk factors and COVI 19 pneumonia who presented with acute ischemic stroke. She was also noted to have ST segment elevation myocardial infarction (STEMI) on the electrocardiogram however the imaging and clinical presentation was consistent with apical takotsubo cardiomyopathy. We here discuss the various pathophysiologic mechanisms by which COVID-19 can result in acute stroke. The patient likely developed takotsubo cardiomyopathy because of stroke and acute COVID-19 induced sympathetic stimulation and catecholamine surge. To the best of our knowledge this is the first case of apical variant of takotsubo cardiomyopathy in a COVID-19 report.
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Kariyanna et al. (2020) conducted a case report in COVID-19, acute ischemic stroke, apical takotsubo cardiomyopathy (n=1). COVID-19 infection was evaluated. A 72-year-old woman with COVID-19 pneumonia and acute ischemic stroke developed apical takotsubo cardiomyopathy, likely due to sympathetic stimulation and catecholamine surge.
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