Key points are not available for this paper at this time.
Describes the mechanism of fibrinogen binding to the platelet GPIIb/IIIa receptor, which is essential for platelet aggregation.
The fibrinogen receptor on platelets is glycoprotein (GP) IIb/IIIa, also known as αIIbβ3. This receptor can bind to immobilized fibrinogen in its resting state. Binding to soluble fibrinogen, however, requires activation of the receptor. This can occur due to inside-out signaling in response to a platelet agonist such as ADP, or directly by agents such as manganese. The interaction between GPIIb/IIIa and fibrinogen is essential in the formation of platelet aggregates (1,2).
No takes yet. Share an insight, caveat, or question.
Dermot Cox (2004) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: