Key result
Elevated carotid-femoral pulse wave velocity was significantly associated with an increased risk of all-cause mortality (HR 1.56) in a high cardiovascular risk Russian cohort over 10 years.
Why the study?
Age-related vascular changes contribute to hypertension and atherosclerosis, prompting an evaluation of the prevalence and survival effects of vascular aging phenotypes in a high cardiovascular risk population.
Does elevated carotid-femoral pulse wave velocity predict all-cause mortality in a high cardiovascular risk Russian population?
Cohort (n=618)
Yes
Does elevated carotid-femoral pulse wave velocity predict all-cause mortality in a high cardiovascular risk Russian population?
Hazard Ratio: 1.56 (95% CI 1.166–2.1)
p-value: p=0.003
Elevated carotid-femoral pulse wave velocity is a significant predictor of all-cause mortality in a high cardiovascular risk population, highlighting the need for population-specific vascular aging definitions.
Changes in the vascular system associated with aging contribute to conditions such as hypertension and atherosclerosis. In this study, we explored the prevalence and survival effects of vascular aging phenotypes in a Russian population, a group with a very high cardiovascular risk according to the SCORE2 scale. A cohort of 618 participants from three metro areas underwent carotid-femoral pulse wave velocity (cfPWV) assessment between 2012 and 2018, with biannual follow-ups to record cardiovascular events and mortality. We compared our data with findings from previously published European cohorts to evaluate methods for classifying vascular aging phenotypes. Our findings indicate that definitions designed for low- and medium-risk populations are of limited use in high-risk groups. Moreover, the association between elevated cfPWV and increased overall mortality suggests a potential selection pressure on vascular aging phenotypes. These insights advance the development of predictive biomarkers for cardiovascular risk in populations with high rates of cardiovascular disease.
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Usoltsev et al. (2025) conducted a cohort in High cardiovascular risk (n=618). Elevated carotid-femoral pulse wave velocity (cfPWV) vs. Normal or lower cfPWV was evaluated on All-cause mortality (HR 1.56, 95% CI 1.166-2.10, p=0.003). Elevated carotid-femoral pulse wave velocity was significantly associated with an increased risk of all-cause mortality (HR 1.56) in a high cardiovascular risk Russian cohort over 10 years.
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