Key result
Cross-correlation method provides the most robust PTT estimation in an arterial simulator with ~1.3% uncertainty.
Why the study?
Arterial stiffness is a key indicator of cardiovascular diseases commonly assessed by PWV via PTT estimation, requiring reliable measurement methods.
Population
Waveforms acquired on a novel arterial simulator with an arterial surrogate
Comparison
Peak-to-peak vs tangent-secant vs cross-correlation PTT estimation methods
Design
In vitro simulation study
Authors
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Hypothesis-generating for PTT methods in simulators; should not change clinical practice pending human validation.
The cross-correlation method is highly robust for estimating pulse transit time in an arterial simulator, which successfully models variable arterial stiffness.
Filippi et al. (2024) studied Arterial stiffness. Cross-correlation method for PTT estimation vs. Peak-to-peak and tangent-secant methods was evaluated on Robustness and uncertainty of PTT estimation. The cross-correlation method was the most robust for estimating pulse transit time in an arterial simulator, with uncertainties below 1.3%.
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