What question did this study set out to answer?

The aim is to assess the anticoagulant effects of edoxaban on various coagulation tests.

Laboratory Measurements of the Oral Direct Factor Xa Inhibitor Edoxaban

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Variable PT/aPTT responses to edoxaban caution against routine monitoring use; leaves open validation of specific assays in clinical settings.

The aim is to assess the anticoagulant effects of edoxaban on various coagulation tests.
Examined the effects of edoxaban on prothrombin time (PT), aPTT, and thrombin generation using human PPP and PRP.
Measured the concentration-dependent prolongation of PT and aPTT in response to edoxaban.
Compared the sensitivity of thrombin generation assay to PT and aPTT.
Edoxaban significantly prolonged PT and aPTT in a concentration-dependent manner.
PT showed substantial variability among different reagents, while aPTT displayed smaller variability.
Thrombin generation assay was three times more sensitive to edoxaban than PT and aPTT.

Morishima et al. (2015) studied this question.

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Variable PT/aPTT responses to edoxaban caution against routine monitoring use; leaves open validation of specific assays in clinical settings.