Genetic disruptions in voltage-gated calcium channel genes, including rare mutations and common single nucleotide polymorphisms, are strongly implicated in the etiology of neuropsychiatric disorders.
This review highlights the role of calcium channel gene mutations in neuropsychiatric disorders and the potential for personalized treatment options.
This review summarises genetic studies in which calcium channel genes have been connected to the spectrum of neuropsychiatric syndromes, from bipolar disorder and schizophrenia to autism spectrum disorders and intellectual impairment. Among many other genes, striking numbers of the calcium channel gene superfamily have been implicated in the aetiology of these diseases by various DNA analysis techniques. We will discuss how these relate to the known monogenic disorders associated with point mutations in calcium channels. We will then examine the functional evidence for a causative link between these mutations or single nucleotide polymorphisms and the disease processes. A major challenge for the future will be to translate the expanding psychiatric genetic findings into altered physiological function, involvement in the wider pathology of the diseases, and what potential that provides for personalised and stratified treatment options for patients.
Heyes et al. (Wed,) conducted a review in Neuropsychiatric disorders (schizophrenia, bipolar disorder, autism spectrum disorders). Genetic disruption of voltage-gated calcium channels was evaluated. Genetic disruptions in voltage-gated calcium channel genes, including rare mutations and common single nucleotide polymorphisms, are strongly implicated in the etiology of neuropsychiatric disorders.
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