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The effect of estradiol-17 3 (estradiol) on gonadotropin releasing hormone (GnRH)-mediated release of luceinizing hormone (LH) was investigated in pituitary cells obtained from ovariectomized ewes during the breeding season, anestrous season or period of transition into or out of the breeding season. In addition, the data suggest that estradiol may depress release of LH during these latter two periods.
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Moss et al. (1980) studied this question.
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