Key result
Internet-based cognitive behavior therapy demonstrated sufficient acceptability and engagement in a 20-patient pilot study to proceed with a 500-patient randomized trial for post-myocardial infarction depression and anxiety.
Why the study?
Does internet-based cognitive behavior therapy improve symptoms of depression and anxiety in patients with a recent myocardial infarction?
Population
Planned 500 patients <75 years old with a recent acute myocardial infarction and depression and/or anxiety…
Comparison
Internet-based cognitive behavior therapy… vs Standard of care according to guidelines.
Design
RCT, 1:1 ratio, stratified by clinical center
Follow-up
14 weeks (primary endpoint), 12 and 24 months (medical data)
Authors
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Supports advancing internet-based CBT to a large post-MI trial; leaves open efficacy for depression and anxiety.
RCT (n=500)
1:1
Yes
Does internet-based cognitive behavior therapy improve symptoms of depression and anxiety in patients with a recent myocardial infarction?
This study protocol outlines a randomized controlled trial to evaluate whether internet-based cognitive behavioral therapy can effectively reduce depression and anxiety in patients recovering from a recent myocardial infarction.
Norlund et al. (2015) conducted an RCT in Recent myocardial infarction with depression and/or anxiety (n=500). Internet-based cognitive behavior therapy (iCBT) vs. Standard of care was evaluated on Change in self-rated anxiety and depression symptoms (HADS) from baseline to end of treatment (14 weeks). Internet-based cognitive behavior therapy demonstrated sufficient acceptability and engagement in a 20-patient pilot study to proceed with a 500-patient randomized trial for post-myocardial infarction depression and anxiety.
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