Population
Neonatal mouse myocytes and adult guinea-pig myocytes
Comparison
Adenovirus AdRMGI-KvLQT1-G306R overexpressing… vs Uninfected cells and cells infected with a…
Design
Preclinical
Follow-up
60-72 h after infection
Authors
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Animal data support dominant-negative KvLQT1 action in LQTS models; leaves open human translation and clinical relevance.
Overexpression of the G306R KvLQT1 mutant significantly reduces native IKs in cardiomyocytes, establishing KvLQT1 as the major molecular component of IKs and confirming a dominant-negative mechanism for this long QT syndrome mutation.
Li et al. (2001) studied this question.
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