What question did this study set out to answer?

To determine the role of acid sphingomyelinase in the antibacterial response against Listeria monocytogenes.

March 1, 2003The Journal of ImmunologyOpen Access

Severe Impairment in Early Host Defense Against Listeria monocytogenes in Mice Deficient in Acid Sphingomyelinase

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Authors

OUOlaf UtermöhlenUniversity of Cologne UKUlrike KarowUniversity of Cologne JLJürgen LöhlerLeibniz Institute of Virology (LIV)

Discussion

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Implication

Randomized trial reveals reduced immunity against Listeria monocytogenes in acid sphingomyelinase-deficient mice, suggesting key immune roles for ASMase.

Key Points

To determine the role of acid sphingomyelinase in the antibacterial response against Listeria monocytogenes.
Infection of ASMase(-/-) mice with Listeria monocytogenes
Comparison of susceptibility with wild-type mice
Analysis of immune responses involving cytokines and macrophage function.
ASMase(-/-) mice had an LD(50) of approximately 100 CFU compared to approximately 10,000 CFU for wild-type mice.
IFN-gamma, IL-1 beta, and IL-6 responses were similar in ASMase(-/-) and wild-type mice.
ASMase(-/-) macrophages could not restrict Listeria growth in vitro despite intact reactive nitrogen and oxidative burst production.

Cite This Study

Utermöhlen et al. (2003) studied this question.

synapsesocial.com/papers/6a2079ba55fc9dbe73780a69 https://doi.org/10.4049/jimmunol.170.5.2621

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Implication

Randomized trial reveals reduced immunity against Listeria monocytogenes in acid sphingomyelinase-deficient mice, suggesting key immune roles for ASMase.

Severe Impairment in Early Host Defense Against Listeria monocytogenes in Mice Deficient in Acid Sphingomyelinase

Discussion

Member takes

Implication

Key Points

Cite This Study

Severe Impairment in Early Host Defense Against Listeria monocytogenes in Mice Deficient in Acid Sphingomyelinase

Discussion

Member takes

Implication

Key Points

Cite This Study

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