Key result
Post-traumatic stress disorder was associated with increased risk for coronary artery disease, hemorrhagic stroke, and cardiovascular mortality, especially in men with lower socioeconomic status.
Why the study?
Although PTSD is associated with increased CVD incidence, evidence regarding whether this association differs by socioeconomic status remains inadequate.
Does post-traumatic stress disorder increase the risk of incident cardiovascular disease, and is this association modified by socioeconomic status?
Cohort (n=214,996)
Does post-traumatic stress disorder increase the risk of incident cardiovascular disease, and is this association modified by socioeconomic status?
Answers are grounded in this paper and cite their sources.
PTSD is associated with an increased risk of cardiovascular disease, particularly in younger individuals and men with lower socioeconomic status, highlighting the need for targeted preventive measures in these vulnerable groups.
INTRODUCTION: Substantial evidence indicates that post-traumatic stress disorder (PTSD) is associated with an increased incidence of cardiovascular disease (CVD), and differential PTSD-CVD association by socioeconomic status had been suggested. However, there are inadequate evidence on differential association. This study investigated sociodemographic heterogeneity in the association between PTSD and CVD. METHODS: A total of 53,749 patients diagnosed with PTSD in 2004-2018 were recruited from Korean National Health Insurance Database. Date of first diagnosis of PTSD was set as an index date. We recruited 3 controls per each patient, matched by age and sex (N = 161,247). Monthly insurance premiums were used as a surrogate variable for socioeconomic status. Cox proportional hazard model was used to estimate the hazard of incident coronary artery disease, incident stroke, and cardiovascular mortality. We stratified participants by age, sex, and insurance premium to test heterogeneities in the association. RESULTS: PTSD was associated with increased risk for coronary artery disease, hemorrhagic stroke, and cardiovascular mortality. Elevation in risk of cardiovascular disease was more prominent in younger individuals. PTSD increased the risk of coronary artery disease and ischemic stroke more in individuals with lower SES, especially in men. LIMITATIONS: Insurance premium might not fully represent socioeconomic status of individual. Misclassification or misdiagnosis of PTSD by might have introduced biases. CONCLUSIONS: PTSD was associated with increased incidence of CVD, particularly in male patients with low SES. For PTSD patients with lower SES, preventive measures against cardiovascular disease would be able to decrease the disease burden of cardiovascular comorbidity in PTSD.
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Kim et al. (2022) conducted a cohort in Post-traumatic stress disorder (n=214,996). Post-traumatic stress disorder vs. Age- and sex-matched controls without PTSD was evaluated on Incident coronary artery disease, incident stroke, and cardiovascular mortality. Post-traumatic stress disorder was associated with increased risk for coronary artery disease, hemorrhagic stroke, and cardiovascular mortality, especially in men with lower socioeconomic status.
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