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The texture observation has long been the core technique in liquid crystal (LC)-based biosensing. One of the drawbacks of this observational means is the difficulty in quantitative analysis. In this invited paper, we report on our recent attempt to improve the LC-based biosensing technique through the analysis of bovine serum albumin (BSA), a protein standard commonly used in the assay of protein concentration. We propose to overcome the technical limitations in the analysis of LC-based biosensors by considering alternative measuring schemes. By means of the induced changes in electro-optical properties of LCs in the presence of different concentrations of BSA, novel quantitative techniques specific for LC-based biosensors are developed.
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Lee et al. (2015) studied this question.
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