Key result
Swimming exercise ameliorated high fat diet-induced cardiac dysfunction in female mice by decreasing obesity, inducing anti-inflammatory IL-10, and reducing pro-inflammatory TNF-α.
Why the study?
Does exercise ameliorate high fat diet-induced cardiac dysfunction and inflammation in mice?
Population
8-week-old female C57BL/6J mice
Comparison
Exercise combined with high fat diet vs High fat diet alone, normal diet alone, and…
Design
Preclinical
Follow-up
8 weeks
Authors
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Extends anti-inflammatory exercise effects to female obese mouse cardiomyopathy models; leaves open human translation.
Does exercise ameliorate high fat diet-induced cardiac dysfunction and inflammation in mice?
p-value: p=<0.05
Moderate exercise mitigates high fat diet-induced cardiomyopathy in mice by reducing inflammation and obesity.
Kesherwani et al. (2015) studied High fat diet-induced cardiac dysfunction. Exercise (swimming) vs. Sedentary (no exercise) was evaluated on Cardiac dysfunction (ejection fraction and fractional shortening) and inflammation markers (p=<0.05). Swimming exercise ameliorated high fat diet-induced cardiac dysfunction in female mice by decreasing obesity, inducing anti-inflammatory IL-10, and reducing pro-inflammatory TNF-α.
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