Key result
This review summarizes modern views on the genetics, morphology, and pathogenesis of hypertrophic cardiomyopathy, a disease with a highly variable clinical phenotype.
This review provides an overview of the current understanding of the genetics, morphology, and pathogenesis of hypertrophic cardiomyopathy.
Objective. Despite the high frequency — 0,2 % (1:500) population, hypertrophic cardiomyopathy (HCM) is still considered one of the most mysterious and misunderstood diseases of myocardium. Insidious pathology has neither specific anatomical and morphological, nor clinical features which makes it a delayed-action bomb: nobody is capable to predict when and what clinical symptoms develop. The clinical phenotype of HCM varies from latent course when the symptoms are absent till rapid progress of heart failure syndrome and sudden cardiac death due to severe arrhythmia. The review covers modern view on genetics, morphology and pathogenesis of HCM.
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Savchenko et al. (2013) conducted a review in Hypertrophic cardiomyopathy (HCM). This review summarizes modern views on the genetics, morphology, and pathogenesis of hypertrophic cardiomyopathy, a disease with a highly variable clinical phenotype.
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