What question did this study set out to answer?

To explore the impact of high-dose intravenous immunoglobulin on acute myocarditis in a patient.

February 1, 2002Journal of Internal Medicine

High‐dose intravenous immunoglobulin in the treatment of acute myocarditis. A case report and review of the literature

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Why the study?

Does high-dose IVIG improve clinical conditions and LVEF in a patient with acute myocarditis?

Population

1 49-year-old woman with acute myocarditis and an apical thrombus, initial LVEF 30%.

Design

Case_report

Follow-up

1 year

Authors

ATA. TedeschiAzienda Ospedaliera Bolognini Seriate LALorena AiraghiFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico SGSandra L. GianniniGlaxoSmithKline (Switzerland)

Discussion

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Implication

High-dose IVIG was associated with rapid LVEF recovery in acute myocarditis; hypothesis-generating and should not yet change practice.

Key Points

To explore the impact of high-dose intravenous immunoglobulin on acute myocarditis in a patient.
Case report of a 49-year-old woman diagnosed with acute myocarditis based on clinical evaluation.
Initial treatment with captopril and frusemide followed by anticoagulants due to thrombus.
High-dose intravenous immunoglobulin (400 mg kg−1 day−1) administered for 5 days after conventional treatment.
Left ventricular ejection fraction increased from 30% to 75% within 1 week of IVIG treatment.
Patient remained in good health with normal LVEF one year after diagnosis.

Structured PICO

Does high-dose IVIG improve clinical conditions and LVEF in a patient with acute myocarditis?

Population

1 49-year-old woman with acute myocarditis and an apical thrombus, initial LVEF 30%.

Intervention

High-dose intravenous immunoglobulin (IVIG) 400 mg/kg/day for 5 days, added to conventional treatment (captopril, frusemide, heparin, oral anticoagulants).

Outcome

Clinical improvement and left ventricular ejection fraction (LVEF) recoverysurrogate

High-dose IVIG administration was associated with rapid clinical and echocardiographic recovery in a patient with acute myocarditis.

Cite This Study

Tedeschi et al. (2002) studied this question.

synapsesocial.com/papers/6a207b43cbc595e19031831d https://doi.org/10.1046/j.1365-2796.2002.00929.x

Topics

Myocarditis

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High‐dose intravenous immunoglobulin in the treatment of acute myocarditis. A case report and review of the literature

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

High‐dose intravenous immunoglobulin in the treatment of acute myocarditis. A case report and review of the literature

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

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