What question did this study set out to answer?

The study aims to investigate blood coagulation abnormalities in cancer patients by measuring Fibrinopeptide A levels and their correlation with tumor growth.

January 15, 1983Cancer

Abnormalities of blood coagulation in patients with cancer: Fibrinopeptide a generation and tumor growth

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Why the study?

Does anticoagulation affect Fibrinopeptide A levels in patients with advanced carcinoma?

Population

50 patients with advanced carcinoma

Design

Cohort

Follow-up

three years

Authors

FRFrederick R. RicklesFlorida State University RERichard L. EdwardsRutgers, The State University of New Jersey CBC BarbUConn Health

Discussion

Member takes

Implication

Serial FPA monitoring may track cancer progression; leaves open anticoagulation's therapeutic role.

Key Points

The study aims to investigate blood coagulation abnormalities in cancer patients by measuring Fibrinopeptide A levels and their correlation with tumor growth.
Followed fibrinopeptide A levels in 50 patients with advanced carcinoma over three years.
Evaluated the effect of anticoagulation treatment with sodium warfarin and heparin on FPA levels.
Analyzed the association between FPA levels and clinical disease progression.
60% of patients showed activation of blood coagulation at study entry.
Anticoagulation with sodium warfarin reduced FPA levels significantly.
Short-term heparin treatment did not normalize FPA levels in patients tested.

Structured PICO

Does anticoagulation affect Fibrinopeptide A levels in patients with advanced carcinoma?

Population

50 patients with advanced carcinoma

Intervention

Anticoagulation with sodium warfarin or short-term heparin

Outcome

Fibrinopeptide A (FPA) levelssurrogate

Most patients with advanced cancer show evidence of blood coagulation activation, and serial FPA levels may be useful for tracking tumor progression or response to therapy.

Cite This Study

Rickles et al. (1983) studied this question.

synapsesocial.com/papers/6a207cb3e1fa5be4a5f41c5c https://doi.org/10.1002/1097-0142(19830115)51:2<301::aid-cncr2820510223>3.0.co;2-7

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Abnormalities of blood coagulation in patients with cancer: Fibrinopeptide a generation and tumor growth

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Abnormalities of blood coagulation in patients with cancer: Fibrinopeptide a generation and tumor growth

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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Also Consider