Key result
Aggregachromic cyanine probes show highly sensitive turn-on fluorescence detection of heparin down to ~10 nM.
Why the study?
Precise and fast detection of heparin remains a significant challenge for assessing its clinical use.
The newly developed asymmetric cyanine fluorogenic probes allow for ultrasensitive detection of heparin and protamine, which may eventually improve clinical monitoring of anticoagulation.
No takes yet. Share an insight, caveat, or question.
May advance heparin monitoring tools; leaves open clinical translation from animal models.
Kostadinov et al. (2025) studied this question. Aggregachromic Fluorogenic Asymmetric Cyanine Probes was evaluated on Detection of heparin and protamine. Aggregachromic fluorogenic asymmetric cyanine probes exhibited a highly sensitive turn-on fluorescence response to heparin with a limit of detection in the 10-25 nM range.