Designing Fluorescent Sensors of Heparin

When the chloride's away…︁ A heparin sensor that increases in fluorescence intensity by 320 % upon heparin association has been designed by using a novel chloride-dependent mechanism. This increase is due to the displacement of the quenching chloride ions from the local environment of the halide-sensitive quinolinium fluorophore. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2268/2007/z600361_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.