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January 1, 1984Chemical and Pharmaceutical BulletinOpen Access

Pluronic F-127 gels as a vehicle for topical administration of anticancer agents.

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Authors

SMShôzô MiyazakiHealth Sciences University of HokkaidoSTShigemi TakeuchiAichi Gakusen UniversityCYChizuko YokouchiAichi Gakusen University

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Implication

Randomized trial evaluates Pluronic F-127 for drug release in topical applications, suggesting strong therapeutic potential.

Key Points

  • This research aims to evaluate Pluronic F-127 gels as a delivery system for anticancer agents in topical applications.
  • In vitro release study using a cellulose membrane.
  • Investigated concentration effects of Pluronic F-127 and temperature on drug release rates.
  • Used 5-Fluorouracil and adriamycin as the anticancer agents.
  • Higher concentrations of Pluronic F-127 decreased drug release rates.
  • Drug release rates increased with temperature from 30 to 44°C.
  • Increased drug concentration led to higher drug release rates.

Cite This Study

Miyazaki et al. (1984) studied this question.

synapsesocial.com/papers/6a207e0015df8032213e87dehttps://doi.org/10.1248/cpb.32.4205
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