Key result
Sertindole treatment significantly prolonged the QTcF interval by 20 ms (P<0.01) but did not significantly affect QTc dispersion (-1 ms, P=0.41) or Tpeak-Tend duration (+7 ms, P=0.05).
Why the study?
Does sertindole alter surrogate markers of arrhythmia risk (QTc dispersion and Tpeak-Tend) in patients?
Observational (n=37)
Does sertindole alter surrogate markers of arrhythmia risk (QTc dispersion and Tpeak-Tend) in patients?
Sertindole prolongs the QTcF interval but does not significantly increase QTc dispersion or Tpeak-Tend, potentially explaining the absence of Torsade de Pointes associated with its use.
Sertindole-associated QT prolongation may not signal higher arrhythmia risk via these markers; leaves open their superiority over QTcF for torsades prediction.
OBJECTIVE: Recent research suggests that other surrogate markers than QTc, including QTc dispersion and Tpeak-Tend, may better correlate with cardiac arrhythmia risk. While sertindole significantly prolongs the QTc interval, the effects on other markers of arrhythmia risk, such as QTc dispersion and Tpeak-Tend are unknown. METHOD: Digital 12-lead ECG was recorded at baseline and at steady-state in 37 patients switched to sertindole. ECG was analysed for Fridericia-corrected QT duration (QTcF), QT dispersion and Tpeak-Tend. RESULTS: From a baseline QTcF of 407 +/- 22 ms, mean QTcF prolongation during sertindole treatment was 20 +/- 23 ms, P < 0.01. No effect on QTc dispersion was found (-1 +/- 11 ms; P = 0.41). No increased duration of the Tpeak-Tend interval from baseline was found (+7 +/- 21 ms; P = 0.05). CONCLUSION: These findings might be related to the absence of confirmed Torsade de Pointes (TdP) cases related to sertindole exposure, despite sertindole's QTc prolonging effects.
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Nielsen et al. (2010) reported an observational. Sertindole vs. Baseline was evaluated on QTcF prolongation (MD 20 ms, p=<0.01). Sertindole treatment significantly prolonged the QTcF interval by 20 ms (P<0.01) but did not significantly affect QTc dispersion (-1 ms, P=0.41) or Tpeak-Tend duration (+7 ms, P=0.05).
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