Why the study?
Do antipsychotic drugs, particularly sertindole, increase the risk of QTc prolongation and ventricular arrhythmias in patients with schizophrenia?
Population
Patients with schizophrenia
Design
Review
Authors
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QTc monitoring remains prudent with antipsychotics; leaves open whether sertindole-like mechanisms truly mitigate arrhythmia risk in schizophrenia.
Do antipsychotic drugs, particularly sertindole, increase the risk of QTc prolongation and ventricular arrhythmias in patients with schizophrenia?
This review highlights that while antipsychotics cause QTc prolongation, the direct risk of ventricular arrhythmias may not be clear-cut for all agents, as some like sertindole may possess counterbalancing antiarrhythmic mechanisms.
Lindström et al. (2005) studied this question.
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