Key result
Psychotropic drugs, including antipsychotics and tricyclic antidepressants, are associated with an estimated 8% frequency of QTc prolongation and a dose-dependent increased risk of sudden death.
Why the study?
Do psychotropic medications increase the risk of QTc prolongation and sudden cardiac death in psychiatric patients?
Population
Psychiatric patients
Design
Review
Authors
Loading...
Heightens QT prolongation caution with listed psychotropics; confirms HERG/IKr mechanism but leaves clinical risk open.
Do psychotropic medications increase the risk of QTc prolongation and sudden cardiac death in psychiatric patients?
Psychotropic medications, particularly antipsychotics and tricyclic antidepressants, are associated with a dose-dependent increased risk of QTc prolongation and sudden cardiac death, necessitating careful patient selection and risk factor identification.
Álvarez et al. (2009) conducted a review in Psychiatric conditions requiring psychotropic medication. Psychotropic drugs (antipsychotics and antidepressants) was evaluated on QTc prolongation and sudden cardiac death. Psychotropic drugs, including antipsychotics and tricyclic antidepressants, are associated with an estimated 8% frequency of QTc prolongation and a dose-dependent increased risk of sudden death.