Key result
A recent history of preeclampsia is associated with elevated resting muscle sympathetic nerve activity and central arterial stiffness compared to uncomplicated pregnancies.
Why the study?
Is a recent history of preeclampsia associated with elevated central pulse wave velocity and muscle sympathetic outflow compared to uncomplicated pregnancies?
Observational
Is a recent history of preeclampsia associated with elevated central pulse wave velocity and muscle sympathetic outflow compared to uncomplicated pregnancies?
A recent history of preeclampsia is associated with elevated sympathetic nerve activity and arterial stiffness, indicating an elevated cardiovascular risk that may become exaggerated with aging.
May warrant closer CV risk monitoring after preeclampsia; leaves open whether sympathetic and stiffness changes predict incident events.
We demonstrate that resting muscle sympathetic nerve activity is elevated in women with a recent history of preeclampsia relative to women who have recently had uncomplicated pregnancies and without a history of preeclampsia. Structural changes in the central arteries are associated with arterial stiffness following preeclampsia, independent of changes in the sympathetic nervous system. The structural changes are observed in these relatively young previously preeclamptic women, indicating elevated cardiovascular risk. Our data suggest that with aging (and the gradual loss of vascular protection for women, as established by others), this risk will become exaggerated compared with women who have had normal pregnancies.
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Usselman et al. (2020) conducted an observational in Recent history of preeclampsia. Recent history of preeclampsia vs. Women who have recently had uncomplicated pregnancies and without a history of preeclampsia was evaluated on Resting muscle sympathetic nerve activity and arterial stiffness. A recent history of preeclampsia is associated with elevated resting muscle sympathetic nerve activity and central arterial stiffness compared to uncomplicated pregnancies.
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