February 1, 2000European Journal of NeuroscienceOpen Access

Abnormal axonal physiology is associated with altered expression and distribution of Kv1.1 and Kv1.2 K+ channels after chronic spinal cord injury

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Population

Rats with chronic (6-8 weeks postinjury) clip compression spinal cord injury of the thoracic cord at T7

Comparison

K+ channel blockers 4-aminopyridine… vs Control noninjured preparations

Design

Preclinical

Follow-up

6-8 weeks postinjury

Authors

RNRaad NashmiUniversity of Victoria OJOwen JonesUniversity Health Network MFMichael G. FehlingsRutgers, The State University of New Jersey

Discussion

Member takes

Implication

May enhance conduction via Kv1 blockade in chronic SCI axons; leaves open human translation.

Structured PICO

Population

Rats with chronic (6-8 weeks postinjury) clip compression spinal cord injury of the thoracic cord at T7

Intervention

K+ channel blockers 4-aminopyridine (4-AP; 200 microM, 1 mM and 10 mM), alpha-dendrotoxin (alpha-DTX; 500 nM), TEA (10 mM), and CsCl (2 mM)

Comparator

Control noninjured preparations

Outcome

Amplitude and area of compound action potentials (CAP) recorded from dorsal column axonssurrogate

Increased expression and dispersed distribution of Kv1.1 and Kv1.2 K+ channels contribute to abnormal axonal physiology in surviving axons after chronic spinal cord injury.

Cite This Study

Nashmi et al. (2000) studied this question.

synapsesocial.com/papers/6a2080eeca5c5b2ddfa5e55d https://doi.org/10.1046/j.1460-9568.2000.00926.x

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Abnormal axonal physiology is associated with altered expression and distribution of Kv1.1 and Kv1.2 K+ channels after chronic spinal cord injury

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Abnormal axonal physiology is associated with altered expression and distribution of Kv1.1 and Kv1.2 K+ channels after chronic spinal cord injury

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider