Key result
End-stage renal disease altered the age-related increase in carotid augmentation index compared to controls (interaction P<0.001), while aortic pulse wave velocity increased similarly with age.
Why the study?
Does age differentially affect carotid augmentation index and aortic pulse wave velocity in end-stage renal disease patients compared to normal controls?
Case-Control (n=517)
Does age differentially affect carotid augmentation index and aortic pulse wave velocity in end-stage renal disease patients compared to normal controls?
In ESRD patients, aortic pulse wave velocity increases with age similarly to normal controls, but carotid augmentation index increases markedly only in younger ESRD patients.
ESRD modifies age-related carotid augmentation index trajectories; leaves open whether pulse wave velocity better tracks vascular aging across ages.
BACKGROUND: In healthy, normotensive individuals, age-related changes in carotid augmentation index (AI) are more prominent in younger individuals (< 50 years), whereas changes in aortic pulse wave velocity (PWV) are more marked in older individuals (> 50 years). We investigated whether the differential effects of age on AI and PWV also existed in end-stage renal disease (ESRD) patients. METHODS: Two hundred and fifty-seven patients (50% male; mean age, 53.9 +/- 15.0 years) with ESRD and 260 normal controls (52% male; mean age, 51.4 +/- 17.8 years) received a comprehensive evaluation of cardiovascular structure and function. RESULTS: The percent differences in PWV between the younger and older subjects were similar in both ESRD patients (+46.2%) and normal controls (+52.5%). The percent differences in PWV between normal controls and ESRD patients were also similar in both younger (+28.2%) and older (+22.9%) subjects. In contrast, the differences in AI between the younger and older subjects were small in ESRD patients (7.3%) but large in normal controls (19.7%). Furthermore, there was a large difference in AI between normal controls and ESRD patients in the younger (+13.3%) subjects, but no difference in the older subjects (+0.8%) (interaction between study groups and age: p < 0.001). CONCLUSION: Markedly differential effects of age on AI and PWV were observed in ESRD patients. PWV increased with age similarly in both ESRD patients and normal controls, whereas AI increased markedly in the younger but only slightly in the older ESRD patients.
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Hsu et al. (2008) conducted a case-control in End-stage renal disease (n=517). End-stage renal disease vs. Normal controls was evaluated on Carotid augmentation index (AI) and aortic pulse wave velocity (PWV) (p=<0.001). End-stage renal disease altered the age-related increase in carotid augmentation index compared to controls (interaction P<0.001), while aortic pulse wave velocity increased similarly with age.
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