April 10, 2007Cardiology in Review
Clinical Significance of Minor Nonspecific ST-Segment and T-Wave Abnormalities in Asymptomatic Subjects: A Systematic Review
Key result
Isolated minor nonspecific ST-segment and T-wave abnormalities in asymptomatic subjects were associated with an increased risk of coronary mortality (HR 1.24 to 1.66).
Why the study?
Does the presence of minor nonspecific ST-segment and T-wave abnormalities predict incident cardiovascular and coronary events in asymptomatic subjects?
Population
Healthy middle-aged or elderly populations, including men, women, blacks, and whites
Comparison
Presence of minor nonspecific ST-segment and… vs Absence of minor NSSTTA
Design
Systematic_review
Authors
Discussion
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Implication
May prompt enhanced risk stratification in asymptomatic adults; confirms independent prognostic value via Level 1 synthesis.
Study Design
Type
Systematic Review
Structured PICO
Does the presence of minor nonspecific ST-segment and T-wave abnormalities predict incident cardiovascular and coronary events in asymptomatic subjects?
P
Population
Healthy middle-aged or elderly populations evaluated for the prevalence and prognostic significance of minor nonspecific ST-segment and T-wave abnormalities.
E
Exposure
Presence of minor nonspecific ST-segment and T-wave abnormalities (NSSTTA)
C
Comparator
Absence of minor NSSTTA
O
Outcome
Incident cardiovascular and coronary events (including coronary mortality)hard clinical
Main Result
Effect estimate: HR 1.24 to 1.66
Minor nonspecific ST-segment and T-wave abnormalities in asymptomatic individuals are an independent risk factor for coronary and cardiovascular mortality.
Limitations
- Gender, race, and age-specific differences in prognostic significance are not clear because of limited data
- Limited data to determine gender, race, and age-specific differences in prognostic significance
Cite This Study
Kumar et al. (2007) conducted a systematic review in Asymptomatic subjects. Minor nonspecific ST-segment and T-wave abnormalities (NSSTTA) vs. Absence of NSSTTA was evaluated on Coronary mortality (HR 1.24 to 1.66). Isolated minor nonspecific ST-segment and T-wave abnormalities in asymptomatic subjects were associated with an increased risk of coronary mortality (HR 1.24 to 1.66).