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This preclinical study explored the electrophysiological mechanisms and ionic background of aconitine-induced fibrillation in mammalian Purkinje fibers.
The effects of some ions and drugs on the aconitine-induced fibrillation and flutter of the isolated mammalian Purkinje fibers were studied from the alteration of transmembrane potentials with intracellular microelectrodes. The concentration of potassium, sodium or calcium ions contained in the perfusing Tyrode solution was varied in the stage of the fibrillation and flutter, and EDTA, tetrodotoxin and propranolol (β-blocker) were added the perfusate and theirs effects were observed. From the results, the ionic background of the fibrillation was estimated and the differences in nature between the fibrillation induced by aconitine and by other methods were discussed.
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Issei Imanaga (1968) studied this question.
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