Why the study?
Does amiodarone or atropine prevent aconitine-induced dysrhythmias and hemodynamic depression in anesthetized cats?
Population
Anesthetized cats (sodium pentobarbital)
Comparison
Amiodarone and/or atropine pretreatment prior to… vs Control animals receiving aconitine without…
Design
Preclinical
Follow-up
Acute observation (at least 3 hours)
Authors
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Amiodarone and atropine effects in cats should not change practice; leaves open cholinergic mechanisms in aconitine arrhythmogenesis for human studies.
Does amiodarone or atropine prevent aconitine-induced dysrhythmias and hemodynamic depression in anesthetized cats?
Amiodarone and atropine effectively suppress aconitine-induced atrial fibrillation and dysrhythmias in a cat model, suggesting a cholinergic mechanism in aconitine's arrhythmogenesis.
Edward Winslow (1981) studied this question.
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