Expression of the IKr components KCNH2 (rERG) and KCNE2 (rMiRP1) during late rat heart development
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Key result
During late rat embryonic development, KCNE2 is transcribed predominantly in atrial and ventricular myocardium, while KCNH2 is expressed more ubiquitously in cardiac and non-cardiac tissues.
Population
Wistar rat embryos at stages E14.5 to E18.5dpc
Design
Preclinical
Authors
Discussion
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Implication
Hypothesis-generating for fetal IKr assembly in rats; leaves open relevance to human congenital arrhythmias pending validation studies.
Structured PICO
P
Population
Wistar rat embryos at stages E14.5 to E18.5dpc were studied to investigate the spatiotemporal expression pattern of KCNH2 and KCNE2 during late embryonic development.
E
Exposure
In situ hybridization to detect KCNH2 and KCNE2 mRNA
O
Outcome
Spatiotemporal expression pattern of KCNH2 and KCNE2 during late embryonic developmentsurrogate
The co-expression of KCNH2 and KCNE2 in the fetal rat myocardium suggests they assemble to form cardiac IKr channels during late embryonic development.
Cite This Study
Chun et al. (2004) studied Late embryonic development of the rat heart. In situ hybridization of KCNH2 and KCNE2 was evaluated on Spatiotemporal expression pattern of KCNH2 and KCNE2. During late rat embryonic development, KCNE2 is transcribed predominantly in atrial and ventricular myocardium, while KCNH2 is expressed more ubiquitously in cardiac and non-cardiac tissues.
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