Key result
Overexpression of the beta2-adrenergic receptor in the developing mouse heart significantly increased L-type Ca2+ channel current density but did not change slow delayed rectifier K+ channels.
Overexpression of beta2-AR in the developing mouse heart selectively modulates L-type Ca2+ channels but not slow delayed rectifier K+ channels, suggesting compartmentalization of beta2-AR-controlled cAMP.
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Caution against clinical translation from mouse overexpression; leaves open beta2-AR compartmentalization in human cardiac ion channel regulation.
An et al. (1999) studied this question. Overexpression of the beta2-adrenergic receptor (beta2-AR) vs. Transgenic negative (TG-) wild-type mice was evaluated on L-type Ca2+ channel current (ICa) density and slow delayed rectifier K+ channel current (IK,s) density. Overexpression of the beta2-adrenergic receptor in the developing mouse heart significantly increased L-type Ca2+ channel current density but did not change slow delayed rectifier K+ channels.
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