What is the clinical evidence from this study?

Study design: Observational. Population: Cardiovascular disease and cancer. Intervention: Calendar year (1983-2013). Primary outcome: Age-standardized mortality rate.

July 1, 2017Population Health MetricsOpen Access

Comparing trends in mortality from cardiovascular disease and cancer in the United Kingdom, 1983–2013: joinpoint regression analysis

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Key result

Between 1983 and 2013, age-standardized cardiovascular mortality in the UK decreased by 67% while cancer mortality decreased by 18%, resulting in cancer overtaking cardiovascular disease as the leading cause of death in 2011.

Population

UK population mortality data from the World Health Organization database between 1983 and 2013

Design

Cohort

Follow-up

30 years (1983-2013)

Authors

LWLauren WilsonShoklo Malaria Research Unit PBPrachi BhatnagarNewcastle University NTNick TownsendPreventive Cardiology

Discussion

Member takes

Implication

Cancer now leads UK deaths; leaves open whether trends persist post-2013 or generalize elsewhere.

Study Design

Type

Observational

Structured PICO

Population

A retrospective trend analysis of the WHO mortality database for the UK between 1983 and 2013, comparing age-standardized mortality rates from cardiovascular disease and cancer.

Outcome

Age-standardized mortality rates from all cancers, all cardiovascular diseases, and their three most common types, by sex and agehard clinical

Age-standardized mortality from cancer surpassed that of cardiovascular disease in the UK in 2011, driven by a steeper 30-year decline in CVD mortality (67%) compared to cancer (18%).

Limitations

Difficulty assessing cardiovascular disease mortality by death certificates, especially in those over 75 years of age with coexisting conditions.
Coding revisions from ICD-9 to ICD-10 affected records and caused unintended variation in the initial study period.
Low number of cases at younger ages can create less reliable age-standardized rates.
CVD mortality difficult to assess by death certificates, especially in those over 75 years with coexisting conditions
Coding revisions from ICD-9 to ICD-10 affected records and caused unintended variation
Low number of cases at younger ages creates less reliable age-standardized rates

Cite This Study

Wilson et al. (2017) conducted an observational in Cardiovascular disease and cancer. Calendar year (1983-2013) was evaluated on Age-standardized mortality rate. Between 1983 and 2013, age-standardized cardiovascular mortality in the UK decreased by 67% while cancer mortality decreased by 18%, resulting in cancer overtaking cardiovascular disease as the leading cause of death in 2011.

synapsesocial.com/papers/6a2084d7df4cd797f4f42874 https://doi.org/10.1186/s12963-017-0141-5

Topics

Women and heart disease

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