Key result
Endothelin-1 antagonists may be useful for the prevention and treatment of sickle cell crisis by mitigating ET-1-driven vaso-occlusion and inflammation.
Why the study?
Are ET-1 antagonists useful in the prevention and treatment of sickle cell crisis?
Are ET-1 antagonists useful in the prevention and treatment of sickle cell crisis?
Endothelin-1 antagonists are proposed as a potential therapeutic strategy for the prevention and treatment of sickle cell crisis by targeting vaso-occlusion and inflammation.
No change to sickle cell management yet; leaves open ET-1 antagonist evaluation in prospective trials.
Sickle cell crisis may be more complex than a vaso-occlusive event in response to hypoxia. Endothelin-1 (ET-1) is a potent vasoconstrictor and mitogen secreted in response to hypoxia. ET-1 contributes to the vaso-occlusion and inflammation in sickle cell crisis. ET-1 antagonists may be useful in the prevention and treatment of crisis.
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Angerio et al. (2003) studied this question. Endothelin-1 antagonists may be useful for the prevention and treatment of sickle cell crisis by mitigating ET-1-driven vaso-occlusion and inflammation.
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