December 1, 1981The Journal of PhysiologyOpen Access

High‐energy phosphate metabolism and energy liberation associated with rapid shortening in frog skeletal muscle

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Population

Frog sartorius muscles

Comparison

Rapid shortening for 0.3 sec from sarcomere… vs Isometric tetanus at sarcomere length 1.8 mum

Design

Preclinical

Authors

EHEarl HomsherHeart Failure / Cardiomyopathy MIMalcolm IrvingHobart and William Smith Colleges AWA WallnerUniversity of California, Los Angeles

Discussion

Member takes

Implication

Hypothesis-generating in amphibian skeletal muscle; leaves open relevance to mammalian cardiac energetics.

Structured PICO

Population

Frog sartorius muscles

Intervention

Rapid shortening for 0.3 sec from sarcomere length 2.6 to 1.8 mum, beginning after 2 sec of isometric stimulation

Comparator

Isometric tetanus at sarcomere length 1.8 mum

Outcome

High-energy phosphate metabolism (ATP, ADP, AMP, inorganic phosphate, creatine) and energy liberated as heat and worksurrogate

During rapid shortening of frog skeletal muscle, significant unexplained enthalpy is produced, suggesting an exothermic shift in cross-bridge states before ATP splitting.

Cite This Study

Homsher et al. (1981) studied this question.

synapsesocial.com/papers/6a2084f4cd682a52c6f8a040 https://doi.org/10.1113/jphysiol.1981.sp013994

View Full Paper

Ask AI

Bookmark

High‐energy phosphate metabolism and energy liberation associated with rapid shortening in frog skeletal muscle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

High‐energy phosphate metabolism and energy liberation associated with rapid shortening in frog skeletal muscle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider