Key result
Flow mediated dilatation serves as a valuable biomarker for endothelial dysfunction, correlating with disease severity and progression in abdominal aortic aneurysms and peripheral arterial disease.
Why the study?
Does flow mediated dilatation (FMD) serve as a useful biomarker for disease severity and progression in patients with abdominal aortic aneurysms and peripheral arterial disease?
Does flow mediated dilatation (FMD) serve as a useful biomarker for disease severity and progression in patients with abdominal aortic aneurysms and peripheral arterial disease?
Flow mediated dilatation is a promising non-invasive biomarker for assessing endothelial dysfunction, disease progression, and response to surgical intervention in patients with abdominal aortic aneurysms and peripheral arterial disease.
Endothelial dysfunction is one of the hallmarks of atherogenesis, and correlates with many cardiovascular risk factors. One of the features of endothelial dysfunction is the loss of nitric oxide (NO) bioavailability, resulting in derangements in the vasodilatory response of the vessel wall. Flow mediated dilatation (FMD) of the brachial artery is an accepted method for non-invasive assessment of systemic endothelial function. FMD is examined extensively in the context of cardiovascular research, and has been utilised as a routine assessment in large cohorts such as the Framingham Heart Study, Young Finns Study, and Gutenberg Heart Study. However, FMD is less known in the context of vascular surgery research, despite the similarities between the underpinning disease mechanisms. This review will provide a summary of FMD in terms of its history of development and the conduct of the test in research settings. It will further highlight the key literature of FMD as a biomarker for vascular surgeons, particularly in the context of abdominal aortic aneurysms and lower limb peripheral arterial disease.
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Bellamkonda et al. (2017) conducted a review in Abdominal Aortic Aneurysm and Peripheral Arterial Disease. Flow Mediated Dilatation was evaluated. Flow mediated dilatation serves as a valuable biomarker for endothelial dysfunction, correlating with disease severity and progression in abdominal aortic aneurysms and peripheral arterial disease.
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