Key result
M-RIP, a 116-kDa human protein, was identified to bind directly to both the myosin binding subunit of myosin phosphatase and RhoA in vascular smooth muscle cells.
The identification of M-RIP provides a molecular mechanism for how RhoA may regulate myosin phosphatase activity in vascular smooth muscle cells, which is relevant to vascular tone and diseases like hypertension.
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Offers candidate RhoA-myosin phosphatase link in VSMCs; leaves open relevance to human vascular tone or hypertension.
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Surks et al. (2003) studied Abnormal vascular smooth muscle cell contractility. Yeast two-hybrid screening and protein characterization was evaluated on Protein interactions of M-RIP with myosin phosphatase and RhoA. M-RIP, a 116-kDa human protein, was identified to bind directly to both the myosin binding subunit of myosin phosphatase and RhoA in vascular smooth muscle cells.
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