September 1, 1988CirculationOpen Access

Response of the left ventricular end-systolic pressure-volume relation in conscious dogs to a wide range of contractile states.

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Population

Conscious dogs instrumented to determine left ventricular volume from ultrasonic left ventricular internal…

Design

Preclinical

Follow-up

1-2 weeks after instrumentation

Authors

WLWilliam C. LittleInterventional Cardiology CCC P ChengNational Tainan Institute of Nursing TPTim O. PetersonNorth Dakota State University

Discussion

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Implication

PES-VES slope sensitively indexes contractility in dogs; extends experimental mechanics but leaves open human translation.

Structured PICO

Population

Conscious dogs instrumented to determine left ventricular volume from ultrasonic left ventricular internal dimensions and measure left ventricular pressure with a micromanometer

Intervention

Incremental infusion of dobutamine (0, 2, 4, 6, and 8 micrograms/kg/min i.v.) and verapamil (10 mg i.v.) given after autonomic blockade

Outcome

Linearity and slope of the left ventricular end-systolic pressure (PES)-volume (VES) relationsurrogate

The linear PES-VES relation is a reasonable and useful description of the left ventricle in conscious dogs, with its slope serving as a sensitive index of contractile state.

Limitations

Linear extrapolation of the relation beyond the range of data points may not be accurate.

Cite This Study

Little et al. (1988) studied this question.

synapsesocial.com/papers/6a2085b3ca5c5b2ddfa5eb41 https://doi.org/10.1161/01.cir.78.3.736

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Response of the left ventricular end-systolic pressure-volume relation in conscious dogs to a wide range of contractile states.

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Response of the left ventricular end-systolic pressure-volume relation in conscious dogs to a wide range of contractile states.

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider