Population
8 anesthetized open-chest dogs
Comparison
Alteration of contractile state with dobutamine… vs Control contractile state
Design
Preclinical
Authors
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Challenges linear LV relation assumptions in models; leaves open human translation and refined mechanics research.
The study demonstrates that LV end-systolic pressure-volume and dP/dtmax-end-diastolic volume relations are nonlinear at higher volumes, and that increased contractile state enhances this nonlinearity due to length-dependent activation and geometric factors.
Noda et al. (1993) studied this question.
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