Key result
In rats with chronic pulmonary embolism, the right ventricular outflow tract exhibited strong proinflammatory and profibrotic transcriptional responses (8,575 genes changed) compared to the apex (422 genes).
In a rat model of chronic pulmonary embolism, the right ventricular outflow tract undergoes profound proinflammatory and profibrotic transcriptional remodeling compared to the apex.
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Should not yet alter PE management; hypothesis-generating for regional RV remodeling in human CTEPH.
Zagorski et al. (2009) studied Chronic pulmonary embolism. Right ventricular outflow tract vs. Right ventricular apex was evaluated on Transcription responses (gene expression changes ≥1.5-fold). In rats with chronic pulmonary embolism, the right ventricular outflow tract exhibited strong proinflammatory and profibrotic transcriptional responses (8,575 genes changed) compared to the apex (422 genes).
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