Frequency domain modeling of reradiation in highly scattering media

We present a straightforward procedure for frequency domain modeling of reradiation in a highly scattering medium with an arbitrary, finite three-dimensional geometry. We use a finite difference numerical solver to determine the fluence distribution at the excitation wavelength, which is then coupled to the emission wavelength with an array of equivalent reradiating sources. We then calculate the fluence distribution at the emission wavelength with a second, independent numerical simulation with new optical parameters appropriate to the emission wavelength, using the distributed reradiating sources as the excitation. We compare three-dimensional simulations of a fluorophore distributed in a scattering medium with experimental data. We also compare simulations of the Raman reradiation of small diamonds in a scattering medium with experiment.