Comparison of the traditional and nontrditional risk factors of heart desease in woman during perimenopause

Aim of the work: to compare the frequency of occurrence and correspondence of the traditional risk factors of the cardiovascular disease to the nontraditional ones in women during perimenopause.Materials and methods: there were examined 115 women with HD of II stage, 1-2 degree and obesity of I-II degree 50±3,5 years old. Depending on menopause status they were divided: 45 women in perimenopause, 50 women in menopause with 3 years period and 20 practically healthy women in perimenopause as a control group. VEGF concentration was determined by the method of immune-enzyme analysis.Results: it was revealed that in the group of women in menopause was observed the reliable increase of the rate of risk factors of cardiovascular events. Combination of obesity, dyslipidemia, hyperglycemia and the high AP complicates the course of perimenipause period in women. The level of VEGF factor had not the reliable influence on indices of the lipid metabolism (general CS, triglycerides, CS LPLD, CS LPVLD) and BMI in women (p >0,05) in perimenopause period but had the influence of hyperglycemia in premenopause and early menopause periods except CS LPHD and BMI increase and also had the influence on the hyperglycemia level in women in perimenopause.Conclusions: it was established that combination of such RF of CVD as obesity and dyslipidemia essentially complicate the clinical manifestations of climacteric syndrome in women in perimenopause that is proved by the high menopause indices. It was established that at combination of hyperglycemia, dyslipidemia, obesity and high VEGF level the risk of CVD on the SCORE scale increases in women in perimenopause. There was demonstrated the reliable influence of VEGF level on the hyperglycemia and CS LPHD indices in menopause (р<0,05), that gives grounds to consider VEGF as an additional nontraditional RF of CVD in these women