What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Healthy women (menopause transition) (n=132). Intervention: Menopause transition stages vs. Premenopausal stage. Primary outcome: Endothelial-dependent vasodilation measured by brachial artery flow-mediated dilation (FMD) (p=<0.001).

What question did this study set out to answer?

The aim was to assess how endothelial function varies across menopause stages and its relationship with cardiovascular risk factors.

September 12, 2012The Journal of Clinical Endocrinology & MetabolismOpen Access

Endothelial Function Is Impaired across the Stages of the Menopause Transition in Healthy Women

Q: What are the key findings of this study?

Endothelial function measured by brachial artery flow-mediated dilation progressively declined from 9.9% in premenopausal women to 4.7% in late postmenopausal women (P<0.001).

Q: What question did this study set out to answer?

The aim was to assess how endothelial function varies across menopause stages and its relationship with cardiovascular risk factors.

View Full Paper

Ask AI

Bookmark

Key result

Endothelial function measured by brachial artery flow-mediated dilation progressively declined from 9.9% in premenopausal women to 4.7% in late postmenopausal women (P<0.001).

Why the study?

Does the stage of menopause transition affect endothelial function in healthy women?

Population

132 healthy women from the general community aged 22-70 yr, categorized as premenopausal, early…

Comparison

Menopause transition stages vs Premenopausal women

Design

Cross-sectional

Authors

KMKerrie L. MoreauVascular Medicine KHKerry L. HildrethUniversity of Colorado Anschutz Medical Campus AMAmie L. MeditzNational Center for Infectious Diseases

Discussion

Member takes

Implication

Perimenopausal endothelial decline may warrant closer CV monitoring; leaves open whether interventions alter progression in healthy women.

Key Points

The aim was to assess how endothelial function varies across menopause stages and its relationship with cardiovascular risk factors.
Cross-sectional study of 132 healthy women aged 22-70 years
Participants categorized into premenopausal, early perimenopausal, late perimenopausal, early postmenopausal, and late postmenopausal stages
Measured endothelial-dependent vasodilation using brachial artery flow-mediated dilation (FMD) via ultrasound.
Brachial artery FMD showed significant differences among menopause stages (P < 0.001) with highest FMD in premenopausal women (9.9 ± 2.1%)
Progressive declines observed in early perimenopausal (8.2 ± 2.5%), late perimenopausal (6.5 ± 1.9%), early postmenopausal (5.5 ± 1.9%), and late postmenopausal (4.7 ± 1.7%) women
Adjustment for cardiovascular risk factors and vasomotor symptoms did not change the associations (P < 0.001).

Study Design

Type

Cross-Sectional (n=132)

Structured PICO

Does the stage of menopause transition affect endothelial function in healthy women?

Population

132 healthy women from the general community aged 22-70 yr, categorized as premenopausal (n = 33, 32 ± 6 yr), early perimenopausal (n = 20, 49 ± 3 yr), late perimenopausal (n = 22, 50 ± 4 yr), early postmenopausal (n = 30, 55 ± 3 yr), or late postmenopausal (n = 27, 61 ± 4 yr).

Intervention

Menopause transition stages (early perimenopausal, late perimenopausal, early postmenopausal, late postmenopausal)

Comparator

Premenopausal women

Outcome

Endothelial-dependent vasodilation measured by brachial artery flow-mediated dilation (FMD) using ultrasoundsurrogate

Main Result

p-value: p=<0.001

Endothelial function progressively declines starting in the early stages of menopause, highlighting the perimenopausal window as a critical period for adverse changes in cardiovascular risk.

Cite This Study

Moreau et al. (2012) conducted a cross-sectional in Healthy women (menopause transition) (n=132). Menopause transition stages vs. Premenopausal stage was evaluated on Endothelial-dependent vasodilation measured by brachial artery flow-mediated dilation (FMD) (p=<0.001). Endothelial function measured by brachial artery flow-mediated dilation progressively declined from 9.9% in premenopausal women to 4.7% in late postmenopausal women (P<0.001).

synapsesocial.com/papers/6a07b3cd44ff8ad339f69a4e https://doi.org/10.1210/jc.2012-2244

Topics

Women and heart disease

View Full Paper

Ask AI

Bookmark

Implication

Perimenopausal endothelial decline may warrant closer CV monitoring; leaves open whether interventions alter progression in healthy women.

Endothelial Function Is Impaired across the Stages of the Menopause Transition in Healthy Women

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Topics

Endothelial Function Is Impaired across the Stages of the Menopause Transition in Healthy Women

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Also Consider

Topics

Also Consider