Key result
Late perimenopause and lower estradiol were associated with larger carotid adventitial diameters (0.28-mm larger for late perimenopause, P=0.001; 0.07-mm larger per SD lower log estradiol, P=0.023).
Why the study?
Are menopausal status and endogenous sex hormone levels associated with carotid artery adventitial diameter and intima-media thickness in middle-aged women?
Population
483 middle-aged women enrolled in the Pittsburgh and Chicago sites of the Study of Women's Health Across the…
Comparison
Late perimenopause, postmenopause, and… vs Pre- or early perimenopause
Design
Cross-sectional
Authors
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Larger adventitial diameters during late perimenopause may mark early vascular remodeling; leaves open causal links to postmenopausal CV risk pending longitudinal data.
Cross-Sectional (n=483)
Yes
Are menopausal status and endogenous sex hormone levels associated with carotid artery adventitial diameter and intima-media thickness in middle-aged women?
Mean Difference: 0.28
p-value: p=0.001
The menopausal transition and declining estrogen levels are associated with larger carotid adventitial diameter, suggesting peripheral vasculature alterations that may partially explain increased cardiovascular risk postmenopause.
Wildman et al. (2008) conducted a cross-sectional in Menopause (n=483). Menopausal status and endogenous sex hormones vs. Pre- or early perimenopause was evaluated on Common carotid artery adventitial diameter and intima-media thickness (MD 0.28 mm, p=0.001). Late perimenopause and lower estradiol were associated with larger carotid adventitial diameters (0.28-mm larger for late perimenopause, P=0.001; 0.07-mm larger per SD lower log estradiol, P=0.023).
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