Ageing, menopause, and ischaemic heart disease mortality in England, Wales, and the United States: modelling study of national mortality data
Population
National mortality data for England, Wales, and the US for three birth cohorts in census years 1950 to 2000.
Design
Other
Follow-up
1950 to 2000
Authors
Discussion
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Member takes
Implication
Questions menopausal protection as driver of IHD sex differences; leaves open prospective validation of early male mortality acceleration.
Structured PICO
P
Population
National mortality data for England, Wales, and the US for three birth cohorts (1916-25, 1926-35, and 1936-45) in census years 1950 to 2000.
O
Outcome
Fit of models to data for England and Wales and for the US (ischaemic heart disease mortality rates)hard clinical
Sex differences in ischaemic heart disease mortality may be explained by an acceleration in male heart disease mortality at younger ages rather than protective menopausal changes in women.
Cite This Study
Vaidya et al. (2011) studied this question.